AIM:To study the clinical effect of self-nasal septal cartilage with mucosa for the treatment of large coloboma of eyelid after resection of eyelid malignant tumor. METHODS:After upper eyelid malignant tumors were resected,eyelids were restored by self-nasal septal cartilage with mucosa on 7 eyes of 7 cases. RESULTS:Seven cases were followed up for 0.5 to 2 years,and the self-nasal setpal cartilage with mucosa grew well. The morphology and function of the recon-struction of eyelids were well. CONCLUSION:The self-nasal septal cartilage with mucosa for restoring blepharocoloboma after eyelid malignant tumor resection is a convenient and less lesion reconstruction operation of eyelid.