观察Nd∶YAG激光及532nm激光对角膜内皮细胞的影响。 方法：用角膜内皮细胞显微镜分别对Nd∶YAG激光周边虹膜切除术和532nm激光治疗中心性浆液性脉络膜视网膜病变患眼进行角膜内皮细胞观察。 结果：所有行Nd∶YAG激光治疗患者激光术后14d，中央CD减少具有统计学意义（P<0.05）；激光虹膜切除术后14d，中央部位CD减少，有统计学意义（P<0.05）；术后7d，周边部激光爆破处AVE,MIN,CD及6A的变化均具有统计学意义（P<0.05）； 532nm激光光凝治疗CSC后角膜内皮细胞的各项检测指标的改变均无统计学意义。 结论：Nd∶YAG激光周边虹膜切开术对角膜内皮有一定的损伤。532nm激光治疗中心性浆液性脉络膜视网膜病变对角膜内皮细胞造成的影响无统计学意义。

To explore the changes of corneal endothelium after the Nd∶YAG and 532nm laser therapy. METHODS: The corneal endothelia of the eyes which had been subjected to the treatment of peripheral iridectomy by using the Nd∶YAG laser and those subjected to the treatment by using the 532nm laser were observed with corneal endothelium microscope. RESULTS: Among the entire Nd∶YAG laser sufferers 14 days later, in the center of the corneal endothelium, the decrease of the cell density(CD) revealed statistically significant difference (P<0.05). After the treatment of peripheral iridectomy 14 days later, in the center of the corneal endothelium, the decrease of the CD revealed statistically significant difference (P<0.05). 7 days later, in the periphery of the corneal endothelium, average cell area,minimum cell area, CD and percentage of hexagonal endothelium(6A) were analyzed with statistically significant difference (P<0.05). There was no significant correlation between pre- and postoperative central and 6 oclock periphery of corneal endothelium in central serous chorioretinopathy(CSC). CONCLUSION:The Nd∶YAG laser peripheral iridectomy has damage to corneal endothelium. The treatment of CSC by using the 532nm laser has no statistically significant damage to the corneal endothelium