·Pigment epithelium-derived factor(PEDF)is a relative molecular weight 50 000 secreting protein and a member of the serp in super-family.Recent studies demonstrated that PEDF has multiple biological functions,including antiangiogenic,neurotrophic and neuroprotective properties.It has recently been shown that PEDF is the most potential endogenous inhibitor of angiogenesis in eyes.PEDF has a wide prospect for treatment of human neovascular diseases and retinal degenerative diseases.Finding of PEDF brings new hope for treatment of neovascular diseases.Research progresses in PEDF and the relations between PEDF and choroidal neovascular diseases are reviewed.·