AIM: To find a safe, simple resection and cost-effective method for the surgical treatment of conjunctivochalasis through a prospective study with randomized comparison observation on the efficacy of treatment device for conjunctivochalasis oriented and quantitative resection. METHODS: Thirty conjunctivochalasis patients 30 eyes with standard diagnosis criteria in department of Ophthalmology of the Affiliated Putuo Hospital of Shanghai University of Traditional Chinese Medicine from Jan. 2008 to May. 2009 were recruited. Patients were randomly grouped according to the odd or even of the last number of the coding. 15 patients(15 eyes) in odd group received oriented resection and 15 patients(15 eyes) in even group received crescented resection.The improve-ment degrees of symptom release were observed 2,4 and 6 weeks after operation and tears river, BUT and Tasting of chloram-phenicol test essay were tested. RESULTS: The efficacy of symptom release in week 4 was 87% in patient group receiving oriented and quantitative resection with conjunctivochalasis treatment device. The cure rate of conjunctivochalasis in patient group receiving oriented and quantitative resection with conjunctivochalasis treatment device was 87% while 73% in patient group receiving crescented resection. There’s no significant difference(χ2=0.833, P=0.361). In patient group receiving oriented and quantitative resection with conjunctivochalasis treatment device, 87% patients were with recovery of tears river in week 4, 73% patients with BUT≥10 seconds, 53% patient with Tasting of chloram-phenicol test essay positive. In patient group receiving crescented resection, 73% patients were with recovery of tears river in week 4 (χ2 =0.833, P=0.361), 67% patients with BUT≥10 seconds (χ2=0.159, P=0.690), 60% patient with Tasting of chloramphenicol test essay positive (χ2=0.136, P=0.713). There’s no significant difference. CONCLUSION: Both operation by conjunctivochalasis treatment device for oriented and quantitative resection and conjunctivochalasis crescented resection are effective while operation by conjunctivochalasis treatment device for oriented and quantitative resection is more simple and accurate, it’s more suitable for physician with less operation experience.