糖尿病性视网膜病变(diabetic retinopathy,DR)是糖尿病微血管病变在眼部的表现,是<75岁成年人的首要致盲眼病。定期随访检查糖尿病患者的眼底及控制血糖、血压、血脂都有助于降低因视网膜病变而致失明的发生率,但其机制仍不明确。蛋白质组学及其相关技术的发展为蛋白质水平上研究DR的病理生理机制提供了强有力手段,该技术可以一次性研究大量蛋白质。比较蛋白质组学研究结果表明DR并不是由单一蛋白质启动的疾病,而是多种蛋白质共同参与的病理过程。目前,绝大多数鉴定出的差异性蛋白质其功能都不太明确,而且各蛋白质之间存在着复杂的网络调节关系。我们就其在DR蛋白质组学方面的研究进展作一综述。

·Diabetic retinopathy(DR)is a diabetic microvascular disease affecting the eyes,which is a leading cause of blindness in adults under 75 years old.In recent years,regular screening for DR,blood glucose,blood pressure and blood lipid has contributed to lower incidence of blindness due to retinopathy.But still the pathogenesis of DR is unclear.At present,proteomics and related technologies provide a powerful tool to study the intrinsic pathophysiological mechanisms of DR at the molecular level.This technology can study an abundance of proteins at a time and identify the different expressed proteins.Comparative proteomics show that the DR is not activated by a single protein,but by a variety of proteins.At present,the functions of the identified proteins are not very clear,and there is a complex network between the various proteins.This article briefly reviews the recent progress of proteomics in DR.·

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中国浙江省自然科学基金资助项目(No.Y207824)~~