·As the manganese has been applied continually in the imaging studies and experimental researches,its toxic injury has been a hotspot.Many studies have demon-strated that the damage of large accumulation of mangan-ese,as a body trace element,is expressed mainly in the nervous system.This article will summarize the papers concerned with the delivery method,body injury and neurotoxic mechanism of manganese,while man-ganese was applied as an image intensifier.·