AIM:To observe the clinical efficacy of amniotic membrane transplantation for bullous keratopathy(BK) and investigate an effective and feasible treatment for BK. METHODS: Retrospective study of 18 cases with BK treated by amniotic membrane transplantation was conducted,the elapse time of the stimulation symptom of the eyes, the number of the bubbles vanised, the time of amnion dissolving, the time of corneal epithelium completely repair and the vision improvement were evaluated.RESULTS: Of the 18 cases, 10 cases got rid of pain in 3 days after the operation, 18 cases with the vanish of the bubbles, all cases with the amnion dissolved completely in 15 days, no cases had complication of rejection, all the cases with the corneal epithelium completely repaired in 15 days.CONCLUSION: Amniotic membrane transplantation is an effective and reliable treatment for BK with easily obtained and inexpensive materials.