·AIM:To discuss the use of auto extricated hard palate mucosa grafting plates to substitute posterior layer eyelid tissue combined with periorbital superficial muscle aponeurosis system(SMAS)flap transfer for repairing defected anterior layer eyelid skin,and the clinical curative effects for full-thickness eyelid defects caused by reconstruction of injured eyes and eyelid malignant tumor.·METHODS:For all 16 patients 16 eyes with medium to heavily full-thickness eyelid defects larger than or equal to the full length of eyelid,oral hard palate mucosa grafting plates were used to substitute tarsal plates and conjunctivas,and reconstruct posterior layer eyelids;periorbital flood-abundant SMAS flaps were transferred to cover the hard palate mucosa and substitute the defected eyelid skin and muscle layer and reconstruct anterior layer eyelids.Among them,10 cases adopted musculus orbicularis oculi single flaps,3 cases superficial temporal artery flaps,2 cases upper eyelid skin orbicular muscle double flaps,1 case on-eyebrow inversion belt flaps.During the surgery,hard palate mucosa grafting was firstly performed,then periorbital SMAS transfer flaps was designed in accordance with part and range of the eyelid anterior defects,palpebral margins was sutured upon completion,and incised after 3-6 months.·RESULTS:For all patients who were followed up for over 12-36 months,the hard palate mucosa grafting plates and their transfer flaps survived without untoward effects of contraction,dislocation,infection or necrosis.Appearance of eyelids and functional improvements were satisfactory.·CONCLUSION:Hard palate mucosa grafting plates have a similar hardness with that of tarsal plates,good supporting effect,soft mucosa surface,no after-surgery contraction,easy availability,and high survival rate.Periorbital SMAS flaps have similar thickness and color with that of eyelids,abundant flood supply,high viability,simple operation,and minor injuries.Reconstruction of full-thickness eyelid defect with hard palate mucosa grafting combined with periorbital SMAS flap transfer can repair defected skin,tarsal plates and conjunctivas with positive curative effect and highly clinical values.·