AIM:To investigate the effect of peribulbar anesthesia on intraocular pressure(IOP) and ocular amplitude pulse (OPA). METHODS:Thirty-two consecutive adult patients with monocular cataract enrolled in this study.IOP and OPA were measured with dynamic contour tonometer(DCT) before and 3,10 minutes after administration of lidocaine anesthesia.Data were analyzed with software SPSS 11.5. RESULTS:The IOP remained stable in the injected eyes and the non-injected eyes after administration of lidocaine anesthesia.The OPA was significantly decreased after injection of anesthesia agent in the injected eyes.The OPA in the non-injected eyes increased significantly 3 minutes after injection of the anesthesia agent,returning to preinjection level 10 minutes after the injection. CONCLUSION:Peribulbar anesthesia leads to decrease of OPA and shows no effect on IOP in the injected eyes.