·AIM:To investigate the clinical effect and safety of the non-spherical rigid gas-permeable contact lens(RGPCL)for special ametropia.·METHODS:Totally 53 patients 99 eyes with special ametropia from March to December,2009 were divided into six groups:(1)high myopia group 6 eyes;(2)high astigmatism 8 eyes;(3)anisometropia group 15 eyes;(4)high astigmatism+high myopia group(myopia:≥6.00D or astigmatism:≥2.00D,10 eyes);(5)high astigmatism+high myopia+anisometropia group 8 eyes;(6)keratoconus group 48 eyes;(7)mixed astigmatism 2 eyes;(8)special refractive error group(after corneal refractive surgery,2 eyes).The corrected visual acuity between the fitting RGPCL and the frame glass were compared.The corrected visual acuity,fitting lens and wearing situation were recorded.·RESULTS:In patients of wearing mirror frame,the degree of equivalent sphere was(-8.10±5.38)D whereas the degree of RGP was(-6.50±4.13)D.There were statistically significant difference(t=-7.499,P<0.01).Correctted visual acuity of non-spherical RGP lenses(LOGMAR)was(0.02±0.09),lower than that of spectacle lenses(0.14±0.20),and there was statistically significant improvement(t=7.03,P<0.01).After wearing glasses 3 to 6 months,corneal epithelial abrasion occurred in 10 eyes and glasses lost in 3 eyes.·CONCLUSION:The application of non-spherical RGP can correct high myopia astigmatism,keratoconus andthe various high refractive,and has a higher comfort and safety.Patients can adapt to lenses and they are superior to spectacles.No severe complications are observed.·