AIM:To emphasize the importance of mixed eye drops (antibiotics and hormones),and to reduce the incidence of after-cataract. ·METHODS:Totally 118 patients 118 eyes underwent extracapsular cataract extraction,and divided into two groups randomly:ofloxacin eye drops and subconjunctiva injection with dexamethasone 2.5mg postoperatively(54 eyes,group A)and diclofenac sodium eye drops and tobramycin+dexamethasone eyedrops postoperatively (64 eyes,group B). This study was observed by the same doctor with the same supplies.The patients were followed up for 3 to 16months.·RESULTS:The incidence of after-cataract was 24% in group A,and 6% in group B,most of which occurred within 2 months postoperatively. ·CONCLUSION:The local application of antibiotics and hormones eye drops regularly can reduce the incidence of after-cataract postoperatively.