AIM:To investigate the the long-term efficacy of combination of sodium hyaluronate and Ahmed glaucoma valve for refractory glaucoma and the prevention and treatment for surgical complications.METHODS:Twenty-seven patients 27 eyes with refractory glaucoma were treated with sodium hyaluronate and Ahmed glaucoma valve and followed up from 6 to 22 months.RESULTS:Postoperative intraocular pressure(IOP)declined from 46.70±9.31mmHg preoperatively to 18.7±6.85mmHg.Visual acuity was improved to some extent.Displacement of glaucoma valve was found in 1 case and improved with adjustment.Hyphema was found in 2 cases and absorbed with medication.CONCLUSION:Sodium hyaluronate combined with Ahmed glaucoma valve can effectively reduce the IOP in patients with refractory glaucoma and decrease the postoperative complications.