目的:探讨德黑兰HIV患者眼部病变的发生频率及其特点。方法:采用横向研究,选取7个月间收录的141例(282眼,其中男性125例,女性16例)不同程度的HIV患者,每位患者拥有全部的个人资料,包括人口统计信息、HIV传播途径、最近CD4淋巴细胞计数、普通性/血源性病毒和弓形虫病的血清学研究、抗逆转录病毒治疗史以及相关的全身性疾病。结果:患者141例中,HIV涉及眼部病的为15例(10.6%),包括3例结核性脉络膜炎,2例巨细胞病毒性视网膜炎,2例单纯疱疹病毒相关病变,1例HIV相关的视网膜病变,1例眼带状疱疹,1例待定为玻璃体炎以及3例涉及颅神经损伤包括2例凝视麻痹和1例视乳头炎。CD4淋巴细胞计数在涉及眼部病变的患者中比没有涉及眼部病变的患者低(204.7±123.8vs403.7±339.7,P=0.029),但两组间其他相关因素没有差异。结论:在德黑兰,结核性脉络膜炎和神经性眼科疾病损伤是HIV患者最常见的眼部损伤,这与最近发表在发达国家的不一致。

AIM:To determine the frequency of HIV-related ocular involvement and to describe the characteristics of involvement in a special clinic in Tehran.METHODS:In this cross sectional study,141 patients(125 male and 16 female,282 eyes) of HIV-infected patients with various stages of HIV infection that were referred to Center of behavioral diseases were evaluated during a period of 7 months.Every patient had a complete profile including demographic data,method of HIV transmission,recent CD4 T cell lymphocyte count,serological studies for common sexual or blood-born viruses and toxoplasmosis,history of antiretroviral therapy,and associated systemic disease.RESULTS:A total of 141 patients were evaluated.HIV-related ocular involvement was detected in 15 patients(10.6%),including 3 mycobacterium tuberculosis-related choroiditis,2 cytomegalovirusretinitis,2 retinal toxoplasmosis,2 herpes simplex virus-related lesions,1 HIV-associated retinopathy,1 herpes zoster ophthalmicus,1 undetermined vitritis,and 3 cases of cranial nerve involvement including 2 cases of gaze palsy and 1 case of papilitis.In our study,mean CD4 T cell lymphocyte count was fewer in patients with ocular involvement than in patients without ocular involvement(204.7±123.8 vs 403.7±339.7,P=0.029),but there was no difference in other possible associated factors between two groups.CONCLUSION:Mycobacterium tuberculosis-related choroiditis and neurophthalmic lesions are the most common HIV-related ocular involvements in Tehran that is different from those of recent publications in developed countries.

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