AIM:To screen TIGR/myocilin gene(MYOC) mutation in high myopic Chinese children with family history.METHODS:Gene sequencing was performed in exon 3 of the TIGR gene in high myopic Chinese Children.The coding sequence of TIGR exon 3 was screened by capillary electrophoresis sequencing.The sequence alterations were analyzed by bioinformatics.RESULTS:TIGR gene mutation was not found in high myopic patients and normal controls group.CONCLUSION:No identified gene mutation is found in TIGR gene in high myopic Chinese children.