·AIM:To summarise the clinical manifestation and treatment of infusion misdirection syndrome during phacoemulisification.METHODS:There were 8 cases with infusion misdirection syndrome from September 2002 to December 2009.The clinical manifestations of these patients were suddenly heightened intraocular pressure,shallow anterior chamber,iris prolapse,and unsustainable anterior chamber depth through injection of viscoelastic material or heightened perfusion pressure.During that time,all patients had no significant pain,irritability or other symptoms.There was no intraocular hemorrhage by indirect ophthalmoscope examination during and after surgery.One of these 8 patients did not recieve any special handling,others were treated with the main incision suture,packet of eyes to rest and 200g/L mannitol injection rapidly.RESULTS:The one case,without special treatment,was performed anterior vitrectomy and intraocular lens suspension because of posterior capsular rupture during operation.After treatment of other 7 patients,1 patient was still unable to form anterior chamber,so pars plana vitreous cavity puncture was carried out;others formed anterior chamber,one of 7 cases had intraocular pressure heightened once again,so residual viscoelastic was not replaced.All the patients were sutured main incision after surgery.CONCLUSION:Infusion misdirection syndrome during phacoemulisification is one kind of rare complication.If it is treated properly,the physical signs originated by high intraocular pressure can be solved,and phacoemulsification can be finished successfully.