目的:研究血清胰岛素样生长因子-1(IGF-1)与糖尿病性视网膜病变的联系。方法:对25例怀孕的糖尿病患者及按年龄、种族、胎儿期和妊娠期相匹配的25例怀孕的非糖尿病患者的血清IGF-1水平进行测量。结果:怀孕的糖尿病患者血清IGF-1水平与怀孕的非糖尿病患者血清IGF-1水平相比明显升高,24wk分别是366±199μg/L和184±89μg/L(P=0.0001),32wk分别是535±251μg/L和356±89μg/L(P=0.007)。36wk分别是404±166μg/L和264±113μg/L(P=0.003)。在妊娠的28,32,36wk,有明确糖尿病病史的怀孕的糖尿病患者血清IGF-1水平比妊娠期糖尿病患者血清IGF-1水平有明显的升高。在整个妊娠期怀孕的伴有视网膜病变的糖尿病患者血清IGF-1水平比那些不伴有视网膜病的患者血清IGF-1水平明显升高。结论:在妊娠期提高血清IGF-1水平可能增加患糖尿病性视网膜病变的风险。

AIM:To study the association of serum insulin-like growth factor-1(IGF-1)with diabetic retinopathy.METHODS:Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age,ethnicity,parity and period of gestation.Fundus examination was performed in both groups at 28,32 and 36 weeks of gestation.RESULTS:The serum IGF-1 level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics [366±199μg/L vs 184±89μg/L(P=0.0001)at 24 weeks,535±251μg/L vs 356±89μg/L(P=0.007)at 32 weeks and 404±166μg/L vs 264±113μg/L(P=0.003)at 36 weeks of gestation].The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28,32 and 36 weeks of gestation.The serum IGF-1 level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation.CONCLUSION:Increased serum IGF-1 in pregnancy may increase the risks for retinopathy.