目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变化情况。结果:口服滋阴凉血散瘀汤联合光凝治疗组患者12mo时视力提高(62.3%vs43.1%,P=0.037),视野改变(17.0±3.7vs14.9±3.7,P=0.002)及新生血管退缩情况(67.2%vs48.3%,P=0.036)均优于对照组患者。结论:滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变较单纯激光治疗更有效。

AIM:To explore the potentially beneficial clinical effects of traditional Chinese medicine(TCM)combined with photocoagulation for diabetic retinopathy(DR).METHODS:Chinese patients with DR were divided into two groups.A joint treatment group received both the TCM ziyinliangxuesanyutang and photocoagulation,while a control group received only photocoagulation laser treatment.Visual acuity tests,visual field retinal sensitivity tests,and fundus fluorescein angiography(to measure neovascular regression)were performed.Vision was compared between the two groups 1 month,6,and 12 months after treatment.RESULTS:Twelve months after treatment,the recovery of visual acuity(62.3% vs 43.1%,P=0.037)and retinal sensitivity [17.0±3.7 decibels(dB)vs 14.9±3.7dB,P=0.002] as well as neovascular regression(67.2% vs 48.3%,P=0.036)in the joint treatment group were all significantly greater than that of the control group.CONCLUSION:Compared with laser treatment alone,the joint application of TCM and photocoagulation is shown to be more effective than DR treatment method.

R779.6

中国河北省科学技术研究与发展计划基金资助项目（No.0627611105）