目的:研究基质金属蛋白酶(matrix metalloproteinases,MMP)在翼状胬肉中的表达。方法:采用免疫组织化学法,检测翼状胬肉与正常结膜组织中MMP-2,MMP-7和MMP-9的表达,比较两者表达的差异。结果:MMP-2,MMP-7和MMP-9在翼状胬肉各层组织中均有不同程度的表达,MMP-2和MMP-7在血管内皮层及鳞状上皮层中表达强阳性,MMP-9在血管内皮层中表达阳性。MMP-2,MMP-7和MMP-9在正常结膜组织中表达阴性或弱阳性。翼状胬肉组织中MMP-2,MMP-7和MMP-9的表达强于正常结膜组织,差异有显著性(P<0.01)。结论:MMP高表达可能与翼状胬肉的发生及复发有关。

AIM:To investigate the expression of matrix metall-oproteinases(MMP)in pterygium.METHODS:The expression differences of MMP-2,MMP-7 and MMP-9 between human pterygium and the normal conjunctiva tissue were compared with immunohistochemical technique.RESULTS:MMP-2,MMP-7 and MMP-9 were expressed on all layers of pterygium.MMP-2 and MMP-7 were strongly expressed in hemoendothelial layer and squamous epithelium.MMP-9 was expressed in hemoendothelial layer.The positive expression of MMP-2,MMP-7 and MMP-9 in pterygium was stronger than that in the normal conjunctiva tissue(P<0.01).CONCLUSION:Over-expression of MMP may play an important role in the pathogenesis and relapse of pterygium.

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