AIM:To evaluate the clinical results of visual performance after epipolis laser in situ keratomileusis (Epi-LASIK) for moderate to high myopia. METHODS: This retrospective study comprised 256 eyes of 128 patients who underwent Epi-LASIK for the correction of moderate to high myopia. Patients were divided into three groups according to spherical equivalent refraction: group A: <-3.00D,mean-2.11±0.35D, 30 patients(60 eyes);group B: -3.00～-6.00D,mean -4.93±0.68D,46 patients(92 eyes);group C: >-6.00D,mean -8.45±1.62D,52 patients(104 eyes). Epi-LASIK was performed with an automatically epikeratome (Amadeus Ⅱ, AMO,America) and the MEL80 (Carl Zeiss Meditec, Jena, Germany) excimer laser. After laser ablation, the epithelial sheet was repositioned and a therapeutic contact lens was applied to the cornea immediately for 7 days. The enrolled patients were followed up at 1day,7days,1month, 3, 6, and 12 months postoperative intervals. The postoperative vision, refraction,wavefront aberration and haze formation were investigated. RESULTS: One year after the treatment, uncorrective visual acuity(UCVA) of 58 eyes(97%) >1.0 in group A, UCVA of 87 eyes(95%) >1.0 in group B, UCVA of 89 eyes(86%) >1.0 in group C; Spherical equivalent refraction was within 1.00D of attempted refraction in 60(100%) eyes in group A; Spherical equivalent refraction was within 1.00 D of attempted refraction in 92(100%) eyes in group B; Spherical equivalent refraction exceeded±1.00 D of attempted refraction in 7(7%) eyes in group C. Higher order aberration increased signifcantly postoperatively in B and C vs. group A(P<0.05). In group A: grade 0.5 haze was found in 3 eyes(5%)at 1 month postoperatively and in 1 eye(2%)at 3 months postoperatively, all other eyes had no haze; In group B: grade 0.5 haze was found in 6 eyes(7%)at 1 month postoperatively and in 4 eyes(4%)at 3 months postoperatively, all other eyes had no haze; In group C: grade 0.5 haze was found in 10 eyes(10%)at 1 month postoperatively and in 8 eyes(8%)at 3 months postoperatively and in 5 eyes(5%)at 6 months postoperatively, gradeⅠ haze was found in 2 eyes(2%)at 1 month and 3 months postoperatively, all other eyes had no haze.CONCLUSION: One-year visual,refractive,wavefront aberration and haze formation results after Epi-LASIK suggest that it is a safe and effcient method for the correction of moderate to high myopia.