目的:对急性期Vogt-小柳-原田综合征(Vogt-Koyanagi-Harada,VKH)患者的眼底自发荧光(fundusauto fluorescence,FAF)特征进行观察。方法:对9例18眼急性期VKH患者进行眼底荧光血管造影、眼底自发荧光成像检查,并对结果进行比较。结果:急性期VKH眼底检查见多囊状浆液性视网膜脱离。FFA检查早期可见色素上皮水平多发性点状荧光素渗漏,晚期形成多囊状的荧光素积存。FAF检查见浆液性视网膜脱离区呈低自发荧光;低自发荧光区内,尚可见环形或半环形高自发荧光,与FFA渗漏点位置对应。VKH恢复期水肿消退后视网膜复位,黄斑区可见色素紊乱。FAF检查见自发荧光分布基本恢复至正常状态,但黄斑区出现一些点状高自发荧光颗粒散在分布。结论:FAF技术为临床医生研究VKH提供了一种活体观察视网膜色素上皮(RPE)细胞代谢和功能改变的手段。但有关FAF在VKH的应用价值尚需进一步研究。

AIM:To investigate the characteristics of fundus autofluorescence (FAF) in acute Vogt-Koyanagi-Harada (VKH) disease. METHODS: A total of 9 patients 18 eyes with acute VKH were undertaken FAF by a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2, HRA2). Characteristics of FAF images were compared with fundus fluorescein angiography (FFA) images. RESULTS:Early phase of FFA showed multiple areas of hyperfluorescence at the level of the retinal pigment epithelium (RPE)and late phase of FFA revealed multiple pooling of dye in the areas of serous detachment. In FAF imaging, the serous detached retinal areas were observed as hypoautofluorescence due to the blockage. In these hypoautofluorescence areas, hyperautofluorescent ring or semiring could still been seen. The site of these hyperautofluorescent ring corresponded with the leakage point in FFA. After resolution of serous detachment, the autofluorescence distribution returned to normal, while some hyperautofluorescent dots were observed scattered in macula.CONCLUSION:FAF imaging non-invasively visualised sequential metabolism and functional changes in RPE in acute VKH disease. The value of FAF in VKH needs further research.

R773.9

中国甘肃省科技厅科技支撑项目（No.090NKCA093）