AIM:To analyze the relation between the development of high myopia and intraocular pressure (IOP) and to investigate the internal relationship between high myopia and primary open angle glaucoma. METHODS: One hundred and four cases (208 eyes) were randomly divided into two groups. Treatment group received brinzolamide eye drops 3 times a day. Control group received artificial tears eye drops 3 times a day. We performed naked visual acuity, corrected visual acuity, the refractive condition with automatic refractor, slit-lamp microscope, fundus and visual field examination. IOP of each subject was measured with non-contact tonometer. The length of ocular axis was measured with A scan of ultrasound. Having been followed-up for 2 years, statistical analysis was taken to find the differences of two groups in the refractive status, axial length,IOP and visual field.RESULTS: Visual fields of the two groups presented a variety of forms and did not show significant changes in two years. There was statistically difference between the mean IOP or the mean diopter of the treatment group 13.25±4.43mmHg and that of the control group 15.53±4.37mmHg. No significant difference was found in axial lengths between the two groups. But with the axial extension, high myopia diopter increased. CONCLUSION: There may be certain relationship between the development of high myopia and IOP. We must pay more attention to the monitoring of IOP in high myopia and improve the proficiency of primary open angle glaucoma early detection. 