目的:探讨糖尿病视网膜病变(diabetic retinopathy,DR)一些相关患病危险因素。方法:选取2009-09/2011-02在我院门诊就诊及住院的83例DR患者为研究对象,采用回顾性分析,对其临床资料进行统计分析。通过组间对比、单因素分析及多因素分析找出与DR有关的一些患病危险因素。结果:NPDR和PDR两组间对比分析表明:DM病程、HbA1c、眼压、CRA-RI在两组间存在统计学差异。单因素分析结果表明:与DR发生及发病有关的危险因素是CRA-RI、眼压、病程、HbA1c,SBP。经Logistic回归分析,最终有统计学意义的因素有CRA-RI,HbA1c及SBP,是DR发生及发展的危险因素。结论:随着PDR组的病程延长及病情加重,HbA1c越高,CRA-RI越大,而眼压反而比对照组(NPDR)低。就纳入本研究的因素而言,影响DR发生及发展的主要因素有CRA-RI,HbA1c及SBP,而病程在一定程度上影响着DR的发生及发展。

AIM:To investigate the related risk factors associated with diabetic retinopathy(DR).METHODS:DR patients who were hospitalized in our hospital from September 2009 to February 2011 were selected.The retrospective study included 83 cases of clinical data about DR patients.A number of disease-related risk factors of DR were detected through comparison between the two groups,univariate analysis and multivariate analysis.RESULTS:Difference of the related factors such as duration of diabetes mellitus(DM),glycated hemoglobin(HbAlc),IOP,and central retinal artery-resistance index(CRA-RI) between the non-proliferative diabetic retinopathy group(NPDR group) and proliferative diabetic retinopathy group(PDR groups) had statistical significance.Univariate analysis of the risk factors of DR showed:the risk factors such as CRA-RI,IOP,duration of DM,HbAlc and systolic blood pressure(SBP) correlated with the occurrence and development of DR.Logistic regression analysis of the risk factors of DR showed:CRA-RI,HbA1c and SBP finally had statistical significance and correlated with the occurrence and development of DR.CONCLUSION:With the prolonged course and severity of the disease in PDR group,the higher the HbAlc was,the higher CRA-RI became,and the lower IOP was when compared with the control group(NPDR group).According to the factors in this study,the main correlation risk factors of DR were CRA-RI,HbAlc and SBP,duration of DM also influenced the occurrence and development of DR in a certain extent.

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