AIM:To evaluate the effect of combined therapy for amblyopia in children by making use of pattern visual evoked potential(P-VEP) respective spatial frequency stimulating therapy that can exercise hands,eyes and brain,together with after-image test,red-light flicker pleoptics and so on.METHODS:These children were divided into two groups:control group and experimental group.The control group:occlusive therapy with precision work,red flare.The experimental group:conventional methods mentioned above with DV-100 PVEP analysis system to do respective spatial frequency stimulating therapy.RESULTS:The total effective rate and cure rate of respective spatial frequency stimulating therapy in 24 months were higher than those of occlusive therapy with precision work.There was a statistically significant difference between them(P<0.05).CONCLUSION:Respective spatial frequency stimulating therapy can make a high level of compliance and curative effects for amblyopia.It is individualized,recreational and good for mental attitudes,and it is also a new way for amblyopia.