结膜乳头状瘤是结膜上皮组织呈乳头状增生的良性肿瘤,根据发病部位可分为结膜型和角膜缘型。结膜型多见,好发于儿童或青少年;角膜缘型少见,好发于中老年人,过度增生有演变成鳞状上皮细胞癌的可能。结膜乳头状瘤发病原因与人乳头状瘤病毒(HPV)感染有关,而HPV在结膜鳞状上皮细胞癌的发生过程中也起着重要作用。因此对结膜乳头状瘤患者进行常规HPV检测对于治疗和随访是非常重要的。手术切除是结膜乳头状瘤基本的治疗方法,但单纯手术切除复发率高,目前采用多种方法防治复发,包括冷冻及电灼、细胞毒药物及干扰素的应用。我们报道了成功应用多种方法综合治疗1例复发性角膜缘型鳞状上皮乳头状瘤的病例。

Conjunctival papilloma is a benign and epithelial tumour,it can be classified into conjunctiva type and limbus type depending on its site.Compared to the limbus type which is common in middle-aged people the conjunctiva type which usually occurs in children or adolesents is more common.The hyperplasia of conjunctival papilloma may leads to conjunctival squamous cell carcinoma.Conjunctival papilloma can be of viral origin(human papilloma virus,HPV),which is also related to conjunctival squamous cell carcinoma,so it is very important to detect HPV in patients for treatment and follow-up.The common treatment of conjunctival papilloma is sugical excision,but simple treatment is associated with high recurrence rate.Several types of therapy have been described,including liquid nitrogen cryotherapy,cauterization,cytotoxic drug and interferon.We report a case of recurrent limbus-based papilloma treated successfully with combined therapy.

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