AIM:To investigate the histopathologic features and incidence of primary blepharal neoplasms.METHODS:The clinical pathological data of 291 primary blepharal neoplasms in Southwestern Eye Hospital from January 2003 to December 2009 were collected and analyzed retrospectively.RESULTS:Benign blepharal neoplasms were 172 cases(59.1%),the top ten in the ranking in turn were papilloma,pigmented nevus,inflammatory granuloma,dermoid cyst or epidermoid cyst,amyloid degeneration,warts,hemangioma,xanthoma,plasma cell granuloma,trichoepithelioma.Malignant blepharal neoplasms were 119 cases(40.9%),the top five in the ranking in turn were basal cell carcinoma,squamous cell carcinoma(including spindle cell carcinoma),sebaceous gland carcinoma,malignant lymphoma,malignant melanoma.The clinical epidemiological data of the top three malignant blepharal neoplasms were summarized.The eyelid restoration after neoplasms ablation were discussed.CONCLUSION:The classification of blepharal neoplasms was various,the clinical pathological analysis of primary blepharal neoplasms was helpful to correct diagnosis and treatment.