AIM:To learn dry eye prevalence in ophthalmic clinic patients,analyze the influencing factors of dry eye and give the appropriate health guidance.METHODS:Totally 392 cases(180 male cases,212 female cases)in ophthalmic clinic over the age of 20 were given inquiry-style investigations,dry eye examination [including slit lamp examination,SchirmerⅠtest(SⅠt),break-up time(BUT)] to confirm the diagnosis and analyze the influencing factors of dry eye.RESULTS:The prevalence of dry eye was 13.27% with 4.3% of male,8.9% of female.The prevalence of 20 to 39 years old,40 to 59 years old,≥60 years old was 0.5%,6.9%,5.9%(respectively).Younger than 60 years old group had 29 patients(55.8%).There were 34 cases(65.4%) of environmental factors influence,18 cases(34.6%) of systemic diseases and medication,20 cases(38.5%) of eye diseases and medication and 6 cases(11.5%) of no obvious incentive.22 cases(42.3%)coexisted with two or more of these factors.CONCLUSION:Dry eye have downward trend in age of onset,risky factors are age,gender,systemic diseases and medication,eye diseases and medication,working and living environment and so on.We should base on different factors leading to dry eye to give the appropriate health guidance to reduce the occurrence of dry eye and control the symptoms of dry eye.