To study the effects of huoxuelishui method (HXLSM)on EGFmRNAˊs expression on epiretinal membrane(ERM) of traumatic proliferative vitreo-retinopathy(tPVR）and its mechanism of curative and preventive effects on PVR. METHODS: Thirty-two rabbits were selected randomly from 40 healthy adult colored rabbits and induced to tPVR models, then divided into four groups: the first group was treated with sanxuemingmu tablet-huoxuelishui (HXLS) group,the second treated with zhixuequyu tablet-huoxuehuayu(HXHY) group,the third treated with zhulingsan-lishuimingmu(LSMM) group and the model group .The rest 8 formed the blank control group.After the rabbits had been fed and administrated for a month , the visibility of fundus, the degree of PVR and pathologic changes were observed,measured EGFmRNA expression in ERM was observed with immunohistochemistry technique. RESULTS:Compared with model group ,the positive level of EGFmRNA was decreased significantly in HXLS group (P<0.01). Compared with model group, the positive level of EGFmRNA decreased much in HXHY and LSMM group(P<0.05).And the level of EGFmRNA in HXLS group were lower than those in HXHY and LSMM group(P<0.05). The positive level of EGFmRNA in HXLS group was a little higher than those in blank group (P<0.01). The PVR in HXLS group was lighter than that in model group,HXHY and LSMM group. CONCLUSION: HXLSM is the coordination of HXHY method and LSMM method. It could inhibit and cure the formation and development of traumatic PVR by counteracting the expression of EGFmRNA on ECM so as to inhibiting proliferative cell’s hyperplasy.