AIM:To discuss the clinical efficacy of integration of traditional Chinese medicine and western medicine for Vogt-Koyanagi-Harada syndrome. METHODS:All 34 cases (68 eyes) with Vogt-Koyanagi-Harada syndrome were treated with low-dose corticosteroids, immunosuppressive agents combined with treatment based on syndrome differentiation of traditional Chinese medicine. RESULTS:Totally 60 eyes cured, 4 eyes improved, the total effective rate was 94%. Visual acuity was better than 1.0 in 24 eyes, and better than 0.2 in 64 eyes. Visual acuity in 4 eyes was less than 0.2 because of cataract. CONCLUSION:Integration of traditional Chinese medicine and western medicine for Vogt-Koyanagi-Harada syndrome can effectively control inflammation and reduce the dosage of corticosteroids and immunosuppressive agents.