AIM:To observe the effect and safety of orthokeratology rectifying myopia and controlling the development of myopia. METHODS:The myopia of 423 cases (789 eyes) were corrected by orthokeratology, and the changes of corneal condition, vision, dioptre were observed.At the same time, patients under the age of 15,who had worn orthoklenses for over one year were studied. RESULTS:All patients were satisfied with the effect and safety of orthokeratology. CONCLUSION:Orthokeratology as a non-traumatic way rectifying myopia can reduce dioptre and control the development of myopia effectively.