AIM:To explore the speed diversity of lacrimal fluid clearance of fluorescein sodium in dry eye patient. METHODS:Totally 30 cases of dry eye patient were chosen, 6μL of 20g/L Fluress was dropped in their conjunctival sac. The extinction time of fluorescein sodium in it was observed unde slit-lamp and compared with that in 30 cases of normal people. RESULTS:The extinction time of fluorescein sodium in right eye of dry eye patient was 2229.18±488.37s and that in left eye was 2239.71±478.99s. The extinction time of fluorescein sodium in right eye of normal people was 1173.35±161.79s and that in left eye of was 1188.92±200.32s. There was statistical significant difference between the two groups by analysis using Origin 6.0 statistics software(P＜0.01). CONCLUSION: The extinction time of fluorescein sodium in dry eye patient was prolonged than that in normal people. The extension is a compensation mechanism which can benefit patients.