AIM:To discuss the operation effect of retrograde intubation of lacrimal passage with silicone lacrimal drainage tube for treating lacrimal duct obstruction diseases. METHODS:Ball head silicone tube was selected to treat nasolacrimal duct obstruction patients in 68 cases ( 83 eyes),and lead type silicone tube to treat lacrimal canaliculus or common canaliculus obstruction patients in 26 cases ( 37 eyes) by retrograde intubation of lacrimal duct operation. RESULTS:Patients were followed up for 6-12 months, the effective rate of treatment in the ball head silicone tube group reached 87%, and in the lead type silicone tube group reached 73%. CONCLUSION:Retrograde intubation of lacrimal passage with silicone lacrimal drainage tube for treating lacrimal duct obstruction diseases is a simple and effective method,and worthy of clinical application in basic level hospital.