AIM:To observe the clinical efficacy of treatment of retinal vein occlusion with compound xueshuantong capsule. METHODS:Thirty-nine patients diagnosed with retinal vein occlusion were treated with compound xueshuantong capsule.Patients were given 3 capsules each time,three times a day orally,taking 30~90 days.Observation was conducted according to the recovery of visual acuity, absorption of retinal bleeding and macular edema and whether the symptoms improved or not. RESULTS:Treatment was markedly effective in 12 cases(31%),effective in 21 cases(54%),invalid in 6 cases(15%) and total effective in 33 cases (85%). The treatment was found no toxic and side effects. CONCLUSION:Compound xueshuantong capsule is a safe and effective drug for treatment of retinal vein occlusion.