AIM:To study the color Doppler ultrasound evaluation of the therapeutic effect of puerarin in the treatment of diabetic retinopathy (DR). METHODS:Totally 87 patients with DR were treated with normal saline 9g/L 250mL and puerarin 400mg intravenous injection, once a day, 15 days for a course. The application of GEs longle 9 color Doppler ultrasonography by the same line of retinal blood flow probe inspection. RESULTS:Almost 37 cases (43%) of 87 cases were improved in clinical symptoms, and 76 cases (87%) were changed significantly in CRA flow parameters after a course of treatment . CONCLUSION:The dynamic real-time color Doppler ultrasound displays the central retinal artery blood flow parameters and the retinal lesions. It is important to evaluate the situation of the early diagnosis of DR lesions, clinical testing , treatment and prognosis. Puerarin can significantly improve microvascular disease, patients with micro blood clots, lower blood sugar, blood lipids, anti-oxidation, increase blood flow and treat diabetic peripheral neuropathy, insulin resistance and so on. CRA blood flow parameters are the objective indicators DR of evaluating the efficacy of puerarin injection.