AIM: To report the successful use of pars plana vitrectomy (PPV) and polyglactin suture to extract large intraocular foreign body(IOFB). METHODS: We report two cases of large IOFB extraction from cornea assisted with PPV and 7-0 polyglactin suture with computerized tomography scans and pictures of the IOFBs. RESULTS: Both cases underwent vitrectomy, lensectomy, intravitreal injections of 2.5mg Ceftazidime and 1mg Vancomycin Hydrochloride, IOFB removal with 7-0 polyglactin suture via a limbal tunnel incision in the first case, and the original corneal laceration in the second. Laser endophotocoagulation was placed around the retinal break at the impact sites, with silicone oil tamponade in both cases. Inflammation was controlled, with successful anatomic restoration in postoperative follow-up.CONCLUSION: We describe, for the first time, removal of the large IOFBs with coil made with 7-0 polyglactin suture from cornea and to be an effective approach in removing large IOFBs without enlarging the sclerotomy to avoid severe and irreversible damage to the retina.