Corneal injury, cataract, proliferative vitreoretinopathy and glaucoma can all be blindness-causing eye disease, such diseases currently rely mainly on drugs and surgical treatment, but surgery can not prevent their recurrence. In recent years, many researchers discovered that antisense oligonucleotide technology played an important role in eye diseases of the above, and tried to explore a new way to prevent these diseases. This paper briefly reviewed the current research situation of antisense oligonucleotide technology and corneal injury, cataract, proliferative vitreoretinopathy, glaucoma.