AIM: To evaluate the efficacy of non-steroidal anti-inflammatory drugs to relieve the symptoms of dry eye after laser-assisted in situ keratomileusis (LASIK). METHODS: Sixty-six patients (132 eyes) were involved and made a self-controlled study in Shandong Eye Institute from November to October 2010. Based on conventional treatment, only artificial tears drops was used for the left eye, and 1g/L Pranoprofen drops was added for the right eye. According to the frequency of the drops, they were divided into two groups, including group A (4 times/day)and group B (6 times/day). Subjective symptoms, Schirmer test(SⅠt), tear break-up time(BUT), fluorescein staining(FL), rose bengal staining, index of surface variance(ISV) and vertical asymmetry(IVA) were recorded and made a statistical analysis respectively before and 10 days, 1 month after surgery. RESULTS: Compared with the control eyes ,there was a statistically significant difference in all the indicators except ISV and IVA of 10 days after the surgery, and except FL, ISV and IVA of 1 month after the surgery in both group A and group B.There was a statistically significant difference in BUT and rose bengal staining of ten days after the surgery between group A and group B(P<0.05). There was no statistically significant difference in indicators 1 month after the surgery. CONCLUSION:The tendency of ISV and IVA from topography shows a great leap but less specificity to evaluation of dry eye after LASIK. Add with 1g/L Pranoprofen drops after LASIK surgery could relief the symptoms of the dry eye effectively though reduce the inflammation and prolong the tear BUT. Increasing the frequency of the non-steroidal anti-inflammatory drugs could not significantly raise the efficiency of the drugs.