丝裂霉素C，5氟尿嘧啶等抗代谢药物应用于青光眼滤过手术抗瘢痕治疗大大提高了手术的成功率，但因其副作用，研究者们不断寻找一种低毒性、安全、有效、作用持久的抗增殖药物。近年来，随着细胞分子生物学及基因蛋白等技术不断进步，针对青光眼滤过手术抗瘢痕治疗，新的给药途径及新的抗瘢痕药物不断的涌现。本文就过去3a在PubMed上收录的关于青光眼滤过手术最新抗瘢痕治疗的文章作一综述。

There are a number of anti-cicatricial drugs for glaucoma filtration surgery, for example, 5-Fluorouracil(5-FU), mitomycin C(MMC) and so on, but these medicines also have certain complications and side effects. The ophthalmologists are looking for more safe, effective and permanent drugs. In this summary, the author will make the conclusion of these articles published in PubMed from 2009 to 2012 concerning secreted protein acidic and rich in cysteine(SPARC), small interfering RNA(siRNA), Pirfenidone, Sirolimus sustained delivery film, and so on.