AIM:To evaluate the quality of life in glaucoma patients and to explore the factors that affect their quality of life. METHODS:Totally 126 patients with glaucoma were evaluated the quality of life with the National Eye Institute visual function questionnaire. RESULTS:The scores of the patients with glaucoma were generally decreased, especially in patients with the obvious change of the visual acuity and the visual field, elder patients, and people whose physical function was decline, with lower education levels, poorer compliance and no medical insurance and no stable income. There were obvious difference (P<0.05). The multiple factor stepwise linear regression analysis showed that the scores of the quality of life was closely related to the visual function, the age, the income, the compliance behavior, the mentation and the social activity (P<0.05). CONCLUSION:With the protection of visual function in patients with glaucoma, we must pay attention to their social, psychological and other factors and give the enough health education and psychological counseling to improve their quality of life.