AIM:To investigate the treatment effect of compound Anisodine and physical therapy for the treatment of amblypia in over-age children. METHODS:Totally 60 eyes of amblyopic children aged from 12 to 18 were divided into two groups, one group used compound Anisodine and physical therapy (CAPT group), the other was treated with physical therapy only (PT Group) .All patients were regularly checked in the following half year. Visual acuity, pattern-visual evoked potential (P-VEP) before and after treatment were tested and analyzed. RESULTS:After treatment, the effective rate of CAPT group was 50.00% and the PT group was 23.33%, the difference between these two groups was significant on statistics（P<0．05）. The comparison of the P-VEP before and after treatment in CAPT group was significant on statistics（P<0．01）,the latency was reduced and the amplitude was increased. The latency comparison of the P-VEP before and after treatment in PT group was significant on statistics（P<0.05）,but amplitude was not （P >0．05）. Comparing two groups P-VEP after treatment, the CAPT group was significant on statistics（P <0．05）, the latency of the P-VEP was reduced and the amplitude was increased. CONCLUSION: It is a good and effective way for the amblyopia in older children to have additional compound Anisodine treatment.