AIM: To study the early changes of choriodal neovascularization(CNV) one week after photodynamic therapy(PDT). Compare the differences between standard PDT and fast infusion reduced light dose PDT. METHODS: Sixteen cases（19 eyes） with subfoval CNV suffered PDT with visudyne. Of the 19 eyes included, 13 eyes suffered standard PDT (6mg/m² visudyne, injection speed is 3mL/min, the interval time between the injection and exposure to the light is 15 minutes, the wave length of light is 689nm, fluency of the light is 600mW/cm², duration of the light is 83 seconds, dose of light is 50J/cm²), 6 eyes suffered fast infusion reduced light dose PDT (6mg/m² visudyne, injection speed is 6ml/min, the interval time between the injection and exposure to the light is 15 minutes, the wave length of light is 689nm, fluency of the light is 600mW/cm², duration of the light is 42 seconds, dose of light is 25J/cm²).The changes of best-corrected visual acuity (BCVA), letters of early treatment for diabetic retinopathy study (ETDRS). Optical coherence tomography(OCT) before and one week after PDT were compared. Using the software of OCT, the bilaminar foveal thickness (Tf), neuroretinal foveal thickness (Nf), outer high reflectivity band thickness (T) and subretinal fluid thickness (SF) were measured. Compare the changes of every observation indexes pre- and postoperatively as well as their differeces. RESULTS: No significant changes had found in OCT images or visual acuity one week after PDT(P>0.05). All the indexes had no significant differences after PDT or between the groups（P>0.05）. CONCLUSION: There were no changes before and one week after PDT.Compared to standard PDT, fast infusion reduced light dose PDT had no differences.