Abstract:AIM:To investigate the relationship between anthropometric parameters and diabetic retinopathy (DR) in adults with diabetes. METHODS: A hospital-based study was conducted. All patients underwent detailed eye examinations by using slit-lamp lens photographs, and fundus photographs of both eyes were taken from a retinal camera, fundus photographs were graded for DR. Cases (n=326) were confirmed with DR with 40-75 years old, and controls (n=326) were admitted to same hospital for different diseases not related with gynecologic ocular diseases. Cases and controls were matched with 1∶1. Using a structured interviewer-administrated questionnaire that included information on sociodemographic characteristics, lifestyle habits, detailed medical history, simultaneously, all subjects were interviewed, and height, weight, waist circumference(WC) and hip circumference of the subjects were measured. Then, body mass index (BMI) and waist-to-hipratio (WHR) were calculated. The odds ratios (OR) and 95% confidence intervals (CI) of DR for anthropometric measurements were estimated with unconditional multiple logistic regression models. RESULTS: For men, compared with controls, the results of weigh, BMI, and WHR were statistically significant (P<0.05). The findings of WC and hip circumference were highly significant (P<0.05). Adjusted for age, sex, Greater BMI was not significantly associated with DR. WC >80cm was related with DR (OR=2.017, 95%CI: 1.393-2.920, P=0.000). For WHR >0.88, the risk of DR significantly increased (OR=2.041, 95%CI: 1.422-2.929, P=0.001). After adjustment for multiple potential confounders, BMI 18.50-23.99kg/m2 was negative associated with DR (OR=0.427, 95%CI: 0.231-0.791, P= 0.007). Similarly, It was showed increased DR risk with increasing WHR and WC (OR =1.729, 95%CI: 1.163-2.572, P=0.007; OR=1.991, 95%CI: 1.353-2.931, P=0.001, respectively). CONCLUSION: Obesity, especially abdominal obesity or central obesity, has potential clinical implications in the management of DR. Thus, diabetes and DR should be effectively prevented through keeping WC and WHR.
