AIM:To evaluate the efficacy and safety of laser subepithelial keratomileusis (LASEK) treating ametropia after cataract extraction and intraocular lens implantation .METHODS:After cataract extraction and intraocular lens implantation, the ametropia in 42 cases (49 eyes) was treated with LASEK. Postoperative follow-up was 6 months, corneal topography, visual acuity, refractive diopter, corneal haze and any other conditions were recorded.RESULTS:The uncorrected visual acuity was over 1. 0 in 32 eyes (65.3%) ,and over 0. 8 in 42 eyes (85.7%) . 45 eyes (91.8%) were within ±1.0 sphere diopter, 34 eyes (69.4%) were within ±0.5 sphere diopter. 43 eyes (87.8%) were within ±1.0 cylinder diopter, within ±0.5D 31 eyes (63.3%) . Corneal haze was at 0.5 grade in 4 eyes and 0 grade in others at postoperative 6 months. There were no complications such as secondary keratoconus, secondary glaucoma, ablation decentration, etc.CONCLUSION:LASEK for ametropia after cataract extraction and intraocular lens implantation is an effective and safe surgery.