AIM:To evaluate the effect of sodium hyaluronic eye drops on the regularity of corneal surface in dry eye patients.METHODS:We examined 52 cases (91 eyes) who were disbelieved as keratoconus or keratoconus at sub-clinical stage with SchirmerⅠtest (SⅠt) and tear film stability, then used Humphrey corneal topography system to examine corneal irregularity measurement(CIM), shape factor(SF) and mean toric keratometry(TKM) before and after instillation of sodium hyaluronic eye drops.RESULTS:The results of SⅠt were less than 10mm and BUT less than 10s in 54 eyes, there were obvious differences of CIM and SF before and after instillation of sodium hyaluronic（P<0.01）, and no obvious differences of TKM before and after instillation of sodium hyaluronic（P>0.05）. The results of SⅠt and tear film stability were normal in 37 eyes, there were no obvious differences of CIM, SF and TKM before and after instillation of sodium hyaluronic.CONCLUSION:Sodium hyaluronic eye drops can smooth the corneal surface and reduce the false positive rate of corneal topography.