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[摘要]
目的：检测增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)患者玻璃体手术前后房水中血管内皮生长因子(vascular endothelial growth factor， VEGF)的浓度变化，研究VEGF在PDR发病机制中的作用。
方法：收集30例PDR患者玻璃体手术前后的房水标本，以30例无糖尿病的白内障患者作为正常对照组，用酶联免疫吸附分析(enzyme-linked immunosorbent assay， ELISA)方法检测VEGF的浓度。
结果：PDR患者与正常对照组相比，房水中VEGF浓度显著升高，有统计学差异(P<0.05)。PDR患者玻璃体视网膜手术后与手术前相比，房水中VEGF浓度显著降低，有统计学差异(P<0.05)。
结论：VEGF积极参与了PDR的发生发展，并与PDR后期新生血管形成有着密切的关系。
[Key word]
[Abstract]
AIM: To evaluate aqueous humor level of vascular endothelial growth factor(VEGF)in proliferative diabetic retinopathy(PDR)patients before and after vitrectomy.
METHODS: Aqueous humor samples were collected from 30 PDR patients before and after vitrectomy. Thirty cases of cataract patients without diabetes mellitus were chosen as a normal control group. Aqueous humor concentrations of VEGF were determined by enzyme-linked immunosorbent assays(ELISA).
RESULTS: Aqueous humor concentrations of VEGF were significantly greater in PDR patients than in control(P<0.05). VEGF concentrations decreased significantly in postoperative samples than that in preoperative samples(P<0.05).
CONCLUSION: VEGF actively takes part in the occurrence and development of PDR, and has a close relationship with neovascularization in the late stage of PDR.
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