PDR患者玻璃体手术前后房水中VEGF水平的变化
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Alterations of the level of VEGF in the aqueous humor of PDR patients before and after vitrectomy
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    摘要:

    目的:检测增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)患者玻璃体手术前后房水中血管内皮生长因子(vascular endothelial growth factor, VEGF)的浓度变化,研究VEGF在PDR发病机制中的作用。

    方法:收集30例PDR患者玻璃体手术前后的房水标本,以30例无糖尿病的白内障患者作为正常对照组,用酶联免疫吸附分析(enzyme-linked immunosorbent assay, ELISA)方法检测VEGF的浓度。

    结果:PDR患者与正常对照组相比,房水中VEGF浓度显著升高,有统计学差异(P<0.05)。PDR患者玻璃体视网膜手术后与手术前相比,房水中VEGF浓度显著降低,有统计学差异(P<0.05)。

    结论:VEGF积极参与了PDR的发生发展,并与PDR后期新生血管形成有着密切的关系。

    Abstract:

    AIM: To evaluate aqueous humor level of vascular endothelial growth factor(VEGF)in proliferative diabetic retinopathy(PDR)patients before and after vitrectomy.

    METHODS: Aqueous humor samples were collected from 30 PDR patients before and after vitrectomy. Thirty cases of cataract patients without diabetes mellitus were chosen as a normal control group. Aqueous humor concentrations of VEGF were determined by enzyme-linked immunosorbent assays(ELISA).

    RESULTS: Aqueous humor concentrations of VEGF were significantly greater in PDR patients than in control(P<0.05). VEGF concentrations decreased significantly in postoperative samples than that in preoperative samples(P<0.05).

    CONCLUSION: VEGF actively takes part in the occurrence and development of PDR, and has a close relationship with neovascularization in the late stage of PDR.

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李双,付汛安. PDR患者玻璃体手术前后房水中VEGF水平的变化.国际眼科杂志, 2012,12(12):2373-2375.

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  • 收稿日期:2012-07-30
  • 最后修改日期:2012-11-21
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