AIM: To observe the application of bioadhesive fibrin adhesive and epidermal growth factor( EGF)instead of the conventional sutures in the ocular pterygium surgery.

METHODS: Totally 78 eyes in 60 cases of pterygium patients were divided into 2 groups according to the limbal violations range. Group A for the range of less than 1/2, a total of 28 cases, 34 eyes; Group B was greater than or equal to the range of 1/2, with a total of 44 eyes in 32 cases; each group was randomly divided into two groups A1, A2, B1, B2, one using absorbable sutures, the other using the improved adhesive fibrin paste method. The operation time, post-operative pain sensation, recurrence rate, and the ocular surface epithelial healing time were compared between the four groups.

RESULTS: The operation time between the group A1 and A2, B1 and B2 had significant differences(P<0.05). There was significant difference of pain assessment between the suture group and the fibrin paste group, the paste group was less pain feeling(P<0.05). The corneal epithelial healing were observed after 4 days and 6 days operation time, there was significant difference(P<0.05)of epithelial healing area in the fibrin paste group compared with the suture group. The recurrence rate during 6 months after operation was reduced in fibrin paste group, but there was no significant difference(P>0.05).

CONCLUSION:Using fibrin sealant compound in the pterygium surgery can relieve pain in patients, reduce inflammation, shorten the operation time, avoid the trouble feeling of suture after surgery, accelerate corneal epithelial healing, and reduce the relapse rate.