HIF-1α及VEGF在增生性糖尿病视网膜病变视网膜前膜中的表达
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The expression of HIT-1α and VEGF in proliferative diabetic retinopathy epiretinal membranes
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    摘要:

    目的:研究缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)及其靶基因血管内皮生长因子(vascular endothelial growth factor,VEGF)在增殖型性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)视网膜前膜的表达,探讨其在PDR发生发展中的作用。

    方法:针对26例PDR Ⅴ~Ⅵ期患者,行玻璃体切除+剥膜术(有合并视网膜脱离者加行视网膜复位术),术中取出视网膜前膜行免疫组织化学染色,观察视网膜前膜中HIT-1α与VEGF和血管内皮标志物CD34的表达。同时行术前血糖、甘油三脂、糖化血红蛋白、是否合并视网脱进行分类并行多因素Logistic回归分析。

    结果:PDRⅤ~Ⅵ期视网膜前膜血管内皮细胞中,表达HIT-1α者24例(92.3%),VEGF者15例(57.7%),血管内皮标志物CD34者26例(100%)。血管内皮标志物CD34分别与HIT-1α(r=0.556,P=0.028)和VEGF(r=0.745,P=0.001)直线相关。 术前血糖、甘油三脂、糖化血红蛋白、是否合并视网脱是PDR视网膜前膜中表达因子HIT-1α,VEGF和CD34表达的相关因素。

    结论:HIT-1α和VEGF在糖尿病视网膜病变视网膜前膜中明显表达。HIT-1α和VEGF可能在PDR的发病中起重要作用。

    Abstract:

    AIM:To investigate the expression of the hypoxia-inducible factor-1α(HIF-1α)and the protein products of its target gene vascular endothelial growth factor(VEGF)in proliferative diabetic retinopathy(PDR)epiretinal membranes.

    METHODS: Totally 26 patients who have been obtained epiretinal membranes(PDRⅤ-Ⅵ)were performed pars- plana vitrectomy. They were removed the epiretinal membrane intraoperation and to observe HIF-1α, VEGF and expression of vascular endothelial marker CD34 in epiretinal membranes through immunohistochemical method.

    RESULTS:Vascular endothelial cells of PDR expressed HIF-1α in 24 cases(92.3%)and VEGF in 15 cases(57.7%)in membranes, respectively. There were significant correlations between the numbers of blood vessels expressing CD34 and HIF-1α(r=0.556, P=0.028). There were significant correlations between the numbers of blood vessels expressing CD34 and VEGF(r=0.745,P=0.001).

    CONCLUSION:HIF-1α and VEGF may play an important role in the pathogenesis of PDR.

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曹建峰,庞东渤,叶文婕. HIF-1α及VEGF在增生性糖尿病视网膜病变视网膜前膜中的表达.国际眼科杂志, 2013,13(5):857-860.

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  • 收稿日期:2013-02-19
  • 最后修改日期:2013-04-25
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  • 在线发布日期: 2013-05-06
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