方法：采集门诊常见的多种原因引起的干眼140例，按照其突出体征分成三类。第一类：睑板腺功能障碍(meibomian gland dysfunction，MGD)的干眼60例，分成A₁组(睑缘治疗组)和B₁组(对照组)各30例； 第二类：角膜上皮损伤为主(角膜荧光染色FL评分≥5分)的干眼50例，分成A₂组(戴角膜绷带镜组)和B₂(对照组)各25例； 第三类：泪液低分泌(泪液分泌试验Schirmer Ⅰ≤5mm/5min)的干眼30例，分成A₃组(泪小点栓塞组)和B₃(对照组)各15例。前两类均运用1g/L艾氟龙眼液和1g/L玻璃酸钠眼液，其中A₁组加睑缘清洗及口服强力霉素，A₂组配戴角膜绷带接触镜治疗。第三类运用10g/L环孢霉素A眼液和卡波姆眼凝胶，其中A₃组全部下泪小点栓塞后用药。随访2wk，记录三类个性治疗组(A₁组、A₂组、A₃组)与相应对照组(B₁组、B₂组、B₃组)治疗前和治疗2wk后的主观症状评分、角膜荧光染色(FL)评分、泪膜破裂时间(BUT)、基础泪液分泌试验(SⅠt)。采用t检验及配对t检验进行统计分析，比较各类中两组治疗前后及两组间以上指标的差异。

结果：干眼140例个性治疗组(A₁组、A₂组、A₃组)与相应对照组(B₁组、B₂组、B₃ 组)治疗前各项指标比较无差异。个性治疗组(A₁ 组、A₂ 组、A₃组)与其治疗前、与相应对照组(B₁组、B₂组、B₃组)治疗2wk后比较，在主观症状评分和BUT两个方面均有统计学差异。A₃ 组(泪小点栓塞组)治疗2wk后观察到下睑缘有明显泪河线形成，与治疗前、与B₃ 组(对照组)比较SⅠt均具有统计学差异。

结论：干眼的治疗在去除病因同时，可针对主要体征，在抗炎和使用人工泪液的基础上，进行相应有效的个性化治疗，能快速缓解干眼症状，稳定泪膜。干眼个性化治疗具有重要意义。

METHODS: Totally 140 cases(140 eyes)of dry eye were divided into three categories according to eye symptoms. First category: 60 cases(60 eyes)with meibomian gland dysfunction(MGD)were divided into A₁ group(palpebralis margin treatment group)and B₁ group(control group); Second category: 50 cases(50 eyes)with corneal epithelium damage(corneal fluorescence staining FL Score≥5)were divided into A₂ group(bandage contact lens group)and B₂ group(control group); Third category: 30 cases(30 eyes)with low Schirmer test(Schirmer Ⅰ≤5mm)were divided into A₃ group(lacrimal punctum plug group)and B₃ group(control group). Both former categories treated by 1g/L fluorometholone eye drops and 1g/L hyaluronate sodium eye drops, but received limbus palpebralis cleaning, oral doxycycline in A₁ group and bandage contact lens in A₂ group else. The third category was treated by 10g/L cyclosporine A and carbomer eye gel, but lacrimal punctum plug in A₃ group before received the drug treatment. Two weeks follow up, each case was examined by subjective symptom, cornea fluorescence colouration test, tear break-up time(BUT), and Schirmer test Ⅰ(SⅠt)in the treatment groups(A₁,A₂,A₃)and the control groups(B₁,B₂,B₃), the results pre- and post-treatment were compared. The t test was used for inferential statistics.

RESULTS: There was no statistical difference between treatment groups(A₁, A₂, A₃)and control groups(B₁, B₂, B₃)before treatment. Two weeks after treatment, there was statistical difference between the treatment groups(A₁, A₂, A₃)and control groups(B₁, B₂, B₃)in subjective symptoms and BUT. The difference among A₃ group(lacrimal punctum plug group, in which the lacrimal river line formed were observed 2 weeks after treatment)and B₃ (control group)was statistically significant in SⅠt.

CONCLUSION:On base of anti-inflammatory and use of artificial tears, individualized therapy is an effective and satisfactory clinical curative method in the treatment of dry eye.