AIM:To evaluate the efficacy of individualized therapy on dry eye induced by different reasons.

METHODS: Totally 140 cases(140 eyes)of dry eye were divided into three categories according to eye symptoms. First category: 60 cases(60 eyes)with meibomian gland dysfunction(MGD)were divided into A₁ group(palpebralis margin treatment group)and B₁ group(control group); Second category: 50 cases(50 eyes)with corneal epithelium damage(corneal fluorescence staining FL Score≥5)were divided into A₂ group(bandage contact lens group)and B₂ group(control group); Third category: 30 cases(30 eyes)with low Schirmer test(Schirmer Ⅰ≤5mm)were divided into A₃ group(lacrimal punctum plug group)and B₃ group(control group). Both former categories treated by 1g/L fluorometholone eye drops and 1g/L hyaluronate sodium eye drops, but received limbus palpebralis cleaning, oral doxycycline in A₁ group and bandage contact lens in A₂ group else. The third category was treated by 10g/L cyclosporine A and carbomer eye gel, but lacrimal punctum plug in A₃ group before received the drug treatment. Two weeks follow up, each case was examined by subjective symptom, cornea fluorescence colouration test, tear break-up time(BUT), and Schirmer test Ⅰ(SⅠt)in the treatment groups(A₁,A₂,A₃)and the control groups(B₁,B₂,B₃), the results pre- and post-treatment were compared. The t test was used for inferential statistics.

RESULTS: There was no statistical difference between treatment groups(A₁, A₂, A₃)and control groups(B₁, B₂, B₃)before treatment. Two weeks after treatment, there was statistical difference between the treatment groups(A₁, A₂, A₃)and control groups(B₁, B₂, B₃)in subjective symptoms and BUT. The difference among A₃ group(lacrimal punctum plug group, in which the lacrimal river line formed were observed 2 weeks after treatment)and B₃ (control group)was statistically significant in SⅠt.

CONCLUSION:On base of anti-inflammatory and use of artificial tears, individualized therapy is an effective and satisfactory clinical curative method in the treatment of dry eye.