方法：收集高度近视者48例48眼和正常对照组20例20眼，分别测量黄斑中心凹最小厚度、中心凹及周边直径为3mm和6mm两个环形区域内上方、下方、鼻侧、颞侧视网膜平均厚度，比较不同区域视网膜厚度之间的差别。

结果：两组旁中心凹上方视网膜神经上皮层最厚，鼻侧与下方次之，颞侧最薄； 旁周边中心凹鼻侧视网膜神经上皮层最厚，上方与下方次之，颞侧最薄。高度近视组中旁中心凹范围及旁周边中心凹的颞侧和下方视网膜神经上皮层厚度均较正常对照组显著变薄； 高度近视组中旁周边中心凹的鼻侧视网膜神经上皮层厚度较正常对照组薄； 高度近视组中旁周边中心凹上方的视网膜神经上皮层厚度较正常对照组无统计学差异(P>0.05)； 高度近视组中中心小凹及中心凹的视网膜神经上皮层厚度高于正常对照组。

结论：黄斑区域视网膜神经上皮层厚度分布存在区域特异性。高度近视眼的视网膜变薄是确实存在的，主要是旁中心凹区，不是在中心凹。

METHODS: A total of 20 cases 20 eyes of normal subjects and 48 cases 48 eyes of high myopia(spherical equivalent\〖SE\〗 <-6.0D)were underwent examination of optical coherence tomography(Zeiss - Humphrey OCT3000). Fast macular thickness map OCT scans of 6 mm were done well on each eye. The minimum foveal and average foveal(1mm ring on the OCT retinal thickness map)thicknesses, the inner ring(1-3mm)macular thickness and the outer ring macular(3-6mm)thicknesses of superior, nasal, temporal and inferior parafovea retinal thickness were recorded.

RESULTS: The retina thickness at the superior was significantly thicker, and the inferior and nasal sides ofparafovea was thicker than the temporal one at the inner ring(1-3mm)macular. The retina thickness at the nasal sides was significantly thicker, and the inferior and superior of parafovea was thicker than the temporal one at the inner ring(3-6mm)macular. 2)The minimum foveal and average foveal(1mm ring on the OCT retinal thickness map)thicknesses were significantly greater than in the normal group. The inner ring(1-3mm)and all(except the superior)of the outer ring macular(3-6mm)thicknesses were significantly lower in the high myopic eyes than in the normal group. No significant difference was found in the superior of the outer ring macular(3-6mm)thicknesses between the high myopic group and the normal group(P<0.05).

CONCLUSION: Retinal thickness is related with regional variations in correlation within the 6-mm macular region. The attenuation was really existed in high myopia. It was inparafovea area but not fovea.