方法：这是一个单中心，前瞻性，双盲，随机对照试验。研究包括泪液分泌分数小于10mm和泪膜破裂时间(TBUT)小于10s的20例干眼症患者，有干燥和结痂睫毛的20例前睑缘炎患者，上眼睑睑板结膜乳头肥大的20例季节性过敏性结膜炎患者和20例对照组患者。比较泪液分泌的分数，泪膜破裂时间，眼表染色(牛津分级方案)，杯状细胞密度(尼尔森分级方案评估所有患者的印象细胞学和化生分数)。

结果：三组患者和对照组患者在泪液功能测试结果，眼表染色评分，杯状细胞密度和化生分数上有显著差异(P<0.001)。

结论：结果证明这三种疾病的炎症反应造成严重眼表损害，并在局部产生炎症。这种损伤产生非常严重的影响，尤其是对结膜杯状细胞密度和化生。杯状细胞损伤程度与临床研究结果有关联。

METHODS: This was a single-centre, prospective, double-blind, randomised and controlled trial. The study includes 20 dry eye patients with Schirmer 1 scores less than 10mm and a tear film break-up time(TBUT)less than 10s, 20 anterior blepharitis patients with drying and crusting of the eyelashes, 20 seasonal allergic conjunctivitis patients with papillary hypertrophy of the upper eyelid tarsal conjunctiva and 20 control group patients. The Schirmer scores, TBUT scores, ocular surface staining(as graded by the Oxford scheme scale), goblet cell density(as observed using impression cytology and metaplasia scores for all patients evaluated by the Nelson grading scheme)were compared.

RESULTS: Significant differences were identified between these patient groups and the control group in terms of tear functions tests, ocular surface-staining scores, goblet cell density and metaplasia scores(P<0.001).

CONCLUSION: Inflammatory response against these three diseases was demonstrated to cause damage in parallel to the severity of the local inflammation they generate on the ocular surface. We confirmed that this damage has very serious effects, especially on conjunctival goblet cell density and metaplasia. We believe that the degree of this loss in goblet cells is correlated with clinical findings.