方法：对67名男性患者行全麻白内障手术，口服坦索罗辛，每日0.4mg(32例)或安慰剂(35例)。比较两组术后尿潴留和软盘虹膜综合征发生率。

结果：两组患者年龄，坦索罗辛组：68.16±8.72岁； 安慰剂组：71.37±8.60岁，(P=0.38)。术后坦索罗辛组尿潴留发生率较低(3.1%vs48.6%，P<0.001； Odds ratio=29.28， 95% CI 3.59～238.79)。安慰剂组中1例(2.9%)发生软盘虹膜综合征(P=0.52； Odds ratio=1.03， 95% CI 0.97～1.09)。

结论：全麻白内障手术前口服坦索罗辛可有效防止术后尿潴留，而不增加软盘虹膜综合征发生的风险。

METHODS: In this double blind clinical trial, 67 male candidates of cataract surgery under general anesthesia randomly received oral tamsulosin(0.4mg daily for one week prior to cataract surgery, n=32), or placebo(n=35). Rates of post-operative urinary retention and floppy iris syndrome were compared between the two groups.

RESULTS: The two groups were matched for the patients' age(tamsulosin group: 68.16±8.72 years, placebo group: 71.37±8.60 years, P=0.38). Post-operative urinary retention occurred less frequently in tamsulosin receivers(3.1% vs 48.6%, P<0.001, Odds ratio=29.28, 95% CI 3.59-238.79). There was only one case(2.9%)with floppy iris syndrome in the control group(P=0.52, Odds ratio=1.03 95% CI 0.97-1.09).

CONCLUSION: Short-term prophylactic administration of oral tamsulosin before cataract surgery on general anesthesia is effective in preventing post-operative urinary retention without increasing the risk of floppy iris syndrome.